Harmony of Dissonance is set in the fictional universe of the Castlevania series. The premise of the series is the eternal conflict between the vampire hunters of the Belmont clan and the immortal vampire Dracula. Harmony of Dissonance takes place in 1748, fifty years after Simon Belmont defeated Dracula's curse. A result of Simon's fight against Dracula was that the villagers changed their opinion of him and the Belmont family.