A first-person shooter in the spirit of schlock horror/slasher flicks, the gameplay of Blood is witnessed through the eyes of the player-controlled character, Caleb, and consists of fighting the hordes of various enemies as he traverses the levels of the game. In single player mode, the objective of the player is to lead Caleb in his quest of revenge against his former master: this is achieved by navigating the levels of each separate episode, looking for an exit, until the "boss" level is reached and a showdown against a large opponent takes place. Each episode can be played separately, in no particular order, albeit these are organized to follow the game's storyline.